Figure 6 | Scientific Reports

Figure 6

From: Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons

Figure 6The alternative text for this image may have been generated using AI.

Microarray analysis of neural stem cell-like cells (iNSCs) and GABAergic neuron-like cells (iGNs) induced from hADSCs. (a) Schematics of samples for microarray analysis. The passage numbers of iNSCs are presented as iNSC P0, P1 and P2. (b) Heatmap for differentially expressed genes (P < 0.005, Kruskall-Wallis test with Conover correction for multiple comparisons). The numbers above heatmap depict independent biological replicates of each group. The neuronally differentiated ReN VM and CX cells were used as positive controls of human neurons. The right panel lists Gene Ontology (GO) annotations and example genes for each cluster. (c) Multidimensional scaling of hADSCs, iNSCs, iGNs, ReN VM and CX samples. (d) Heatmap representation of the expression profiles of 8 neural cell- and 4 hADSC-enriched genes at each sample. The numbers above heatmap depict independent biological replicates of each group.

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