Table 1 Biophysical characterisation of vaccine candidates.
Candidate | Epitope | Additional sequences | R* | LAA** | Secondary structure (Determined by CD) | D25 kD (nM) | Mota kD (nM) | Diameter DLS (nm) |
|---|---|---|---|---|---|---|---|---|
ØP1 | Site Ø | — | Ac | — | Random coil | NB | NB | N/A |
ØP2 | Site Ø | GCN4 | Ac | — | Random coil | ~720 | NB | N/A |
IIP3 | Site II | — | Ac | — | Random coil | NB | NB | N/A |
IIP4 | Site II | GCN4 | Ac | — | Random coil | NB | NB | N/A |
IIP5 | Site II | Extended | Ac | — | Random coil | NB | ~22 | N/A |
ØLCP1 | Site Ø | — | Ac | 2 | Mixture of β-sheet, α-helix | NB | NB | 225±10 |
ØLCP2 | Site Ø | GCN4 | Ac | 2 | α-helix | 66 | NB | 40±3 |
IILCP3 | Site II | — | Ac | 2 | β-sheet | NB | NB | 2154±300 |
IILCP4 | Site II | GCN4 | Ac | 2 | α-helix | NB | ~4 | 122±20 |
IILCP5 | Site II | Extended | Ac | 2 | α-helix | NB | ~15 | 181±25 |
IILCP6 | Site II | GCN4 | Ac-C16-C16 | 4 | N/A | NB | ~40 | 419±70 |
IILCP7 | Site II | Extended | Ac-C16-C16 | 4 | N/A | NB | ~14 | 261±20 |
