Figure 6
From: Estradiol Regulates Txnip and Prevents Intermittent Hypoxia-Induced Vascular Injury
Knock-down of Txnip suppressed the apoptosis of HUVECs more significant than E2, while had no difference in oxidative stress. Knock-down of Txnip significantly suppressed the IH-induced apoptosis of HUVECs, and further reduced apoptosis combined with estradiol treatment (n = 5, # P < 0.05 and *P < 0.01, (A and B). The level of MDA decreased (B) and the SOD activity (C) increased when treated with knock-down of Txnip or estradiol (n = 5, # P < 0.05). While, no difference was found in the levels of MDA and SOD between knock-down of Txnip and estradiol treatment (n = 5, ns P > 0.05, (C and D), implying effects of estradiol partially through inhibition of Txnip. siT: siTxnip; siC: cont-siRNA.
