Figure 1
Effect of cannabinoids in mice. The arrow indicates the time of i.p. injection. (A) Injection of ∆9-THC (10 mg/kg) resulted in a high-amplitude EEG shortly after administration. In a magnified view, high-amplitude EEG seizure spikes (in dashed circles) were detected. EMG and LMA were decreased during this period. (B) Injection of the synthetic cannabinoid JWH-018 (2.5 mg/kg) also resulted in high-amplitude EEG and produced seizures, while EMG and LMA were low. (C) Pretreatment with the CB1R-specific antagonist AM-251 (5 mg/kg) 30 min before JWH-018 (2.5 mg/kg) prevented EEG seizures and EMG/LMA suppression. (A–C) n = 6.
