Figure 3 | Scientific Reports

Figure 3

From: Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

Figure 3

LRRK2 kinase-activity dependent phospho-petide and peptide hits identified in the phosphoproteomic and global proteomic studies. Volcano plot visualizations of the mean of log10-transformed CMPD/DMSO treatment ratios versus the CMPD/DMSO ratio standard deviations for (A) all class I phosphorylation sites or (B) all proteins that were quantified in at least five out of eight replicate experiments. Phosphorylation sites and proteins that are classified by the applied mean rank test to be significantly up- or down regulated are depicted in green. The black vertical line (quantified mTRAQ ratio of 1:1, 0 on log10 scale) indicates the boundary between positive (up-regulations) and negative mTRAQ ratios (down-regulations). The dashed lines indicate a two-fold regulation (±0.3 on log10 scale). CMPD, compound (Lu AF58786). DMSO, dimethyl sulfoxide.

Back to article page