Table 2 Inhibition of LRRK2-Ser935 and Rab10-Thr73 phosphorylation.

From: Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

Assay

PFE-360

Cmpd A

IC50

pIC50 ± SEM

IC50

pIC50 ± SEM

LRRK2-pSer935

24 nM

7.6 ± 0.3 (n = 3)

266 nM

6.6 ± 0.1 (n = 3)

Rab10-pThr73

12 nM

7.9 ± 0.3 (n = 3)

104 nM

7.0 ± 0.1 (n = 3)

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