Figure 3
From: A new mild hyperthermia device to treat vascular involvement in cancer surgery
Tumor heat differential and cell death in in vivo murine PDAC model. (A) PDAC tumor is positioned for heat treatment (B) the heating device is placed onto the tumor (C) heat differential between tumor boundary and tumor core (mouse body core temperature is also displayed) (Black arrow depicts the point at which 46 °C in the tumor core was reached and the red arrow indicates the end of the treatment time when the device was removed). (D) and (E) tumor after treatment (yellow scale bar = 2 cm, and yellow arrow represents heated side of tumor) (F) and (G) Row of histological cross-sectional micrographs of tumors treated with hyperthermia as described by Fig. 3A–E (from left to right, (H&E), picro Sirius and Cl-PARP histology stains, red arrows indicate heated surface, black scale bars = 2 mm).
