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Figure 1

From: Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

Figure 1

Age associated differences in probability of symptoms if infected and malaria-associated in vivo Vδ2+ T cell expansion among children in high transmission setting. (A) Increasing parasite prevalence, but lower probability of symptoms given patent infection with increasing age among children in Nagongera, Uganda. Point estimates and 95% confidence intervals derived using multilevel mixed effects logistic regression modeling. (B) Absolute Vδ2 T cell counts at time of malaria and 3, 6, and 9 weeks post-malaria (n = 43, Wilcoxon matched pairs signed-rank). (C) Absolute Vδ2 T cell counts during and after acute malaria episode, stratified by age (0- < 4 yrs, n = 13; 4- < 7 yrs, n = 16; 7–11 yrs, n = 14). Point estimates derived from repeated measures analysis using generalized estimating equations, controlling for Day 0 parasite density.

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