Figure 2
From: Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates
Structural model of transmembrane domains M1-M10 of bATP8A2. The M1-M2 hairpin is coloured purple, M3-M4 green, M5-M6 ochre, and M7-M10 grey. The model was previously published for both E2 and E2P states14 and is here shown for E2P in front (a) and back (b) views, respectively, along the membrane plane, with the side chains of the most important residues mentioned in the text indicated by stick representation (carbon atoms yellow, oxygen red, and nitrogen blue). The exoplasmic side is down and the cytoplasmic side up. Hence, the phospholipid is transported upwards.
