Figure 2

Sensitivity of flux towards synthesis of internal metabolites to specific input metabolite uptakes – Each bar in the plot represents the maximum flux through the synthesis of specific internal metabolites due to specific input metabolites, each synthesis considered as a separate metabolite drain (objective function) in the model. Four different scenarios were considered for optimizing the considered objective functions (synthesis of each separate output metabolite) namely, (A) only one given input at a time; (B) two inputs given at a time, glucose being fixed and a variable second input; (C) two inputs given at a time, one being isoleucine, which is kept fixed and a variable second input; and (D) Three inputs given at a time, glucose, tyrosine are fixed and a variable third input. The details of the designed methodology are further explained in Methods section.