Figure 2
From: Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model
Monkey serum antibody binding to, and CDC of, DKO RMEC and AEC (A) Sera were collected every week for 15 weeks for IgG binding to RMEC and AEC measured by flow cytometry. Histograms in green (control) indicate antibody binding before immunization (0 week), histograms in red indicate antibody binding of immunized monkey serum at the time indicated. (B) Antibody binding to DKO RMEC and AEC using the same immunized serum. Binding to RMEC was significantly higher than to AEC (p < 0.05).(C) Percentage cell death (% cytotoxicity) of DKO RMEC and AEC. Cell death of RMEC was significantly greater than of AEC (p < 0.05).
