Table 2 Fold-changes and p-values of the lipid species combined in an algorithm that differentiates between rapid and slow fibrosers (first four compounds); and of the most significant metabolites discriminating between rapid and slow fibrosers by unpaired Student’s t-test (or by Welch’s t test where unequal variances). Data is expressed as mean ± standard deviation. Sphingomyelin (SM), phosphatidylcholine (PC), taurochenodeoxycholic acid (TCDCA), taurocholic acid (TCA), cholesteryl ester (ChoE), glycocholic acid (GCA).
From: A Metabolomics Signature Linked To Liver Fibrosis In The Serum Of Transplanted Hepatitis C Patients
Fast | Slow | Fold-change | log 2 (fold-change) | Student’s t-test (p) | |
|---|---|---|---|---|---|
SM(38:1) | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.9 | -0.2 | 3.89E-03 |
SM(d18:2/16:0) | 0.8 ± 0.2 | 0.9 ± 0.2 | 0.9 | -0.1 | 5.07E-02 |
PC(16:0/18:0) | 0.8 ± 0.2 | 0.8 ± 0.1 | 1.0 | 0.0 | 7.64E-01 |
PC(16:0/16:0) | 1.3 ± 0.3 | 1.0 ± 0.2 | 1.2 | 0.3 | 2.92E-08 |
TCDCA | 2.7 ± 1.3 | 1.3 ± 0.9 | 2.1 | 1.1 | 2.92E-12 |
TCA | 3.0 ± 1.8 | 1.3 ± 1.2 | 2.4 | 1.3 | 3.71E-11 |
ChoE(18:1) | 0.5 ± 0.2 | 0.6 ± 0.2 | 0.8 | -0.4 | 2.88E-08 |
PC(16:0/16:0) | 1.3 ± 0.3 | 1.0 ± 0.2 | 1.2 | 0.3 | 2.92E-08 |
Tyrosine | 0.7 ± 0.1 | 0.6 ± 0.1 | 1.2 | 0.2 | 4.94E-07 |
GCA | 1.6 ± 0.8 | 1.0 ± 0.7 | 1.6 | 0.6 | 6.39E-07 |
SM(d18:0/18:0) | 1.1 ± 0.4 | 0.9 ± 0.3 | 1.3 | 0.3 | 3.96E-05 |
PC(32:1) | 1.4 ± 0.8 | 1.0 ± 0.4 | 1.5 | 0.6 | 3.97E-05 |
PC(O-20:0/0:0) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.8 | -0.3 | 4.54E-05 |
PC(20:0/0:0) | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.9 | -0.2 | 4.67E-05 |
SM(d18:0/14:0) | 1.1 ± 0.5 | 0.9 ± 0.3 | 1.2 | 0.3 | 6.05E-04 |
