Figure 10
From: Identification of key regions and residues controlling Aβ folding and assembly
Map of individual amino acids important in controlling Aβ folding and assembly. Amino acids with particularly strong effects on assembly are indicated by shading. Amino acids affecting both Aβ40 and Aβ42 are in grey boxes. Amino acids unique to Aβ40 are in green boxes and those unique to Aβ42 are in red boxes. Amino acids that displayed strong effects by one metric but not all are in blue boxes. The C-terminal region of Aβ42, which we found to be especially sensitive to substitution, is indicated by a red box formed with dashed lines.
