Figure 9
From: Identification of key regions and residues controlling Aβ folding and assembly
Morphology of WT and singly substituted Aβ40 and Aβ42. Morphology was examined using negative stain transmission electron microscopy. Electron micrographs of fibrils formed by (A) WT Aβ40, Aβ40 D-L17, Aβ40 D-N27; and (B) WT Aβ42, Aβ42 D-H14, Aβ42 D-F20, Aβ42 D-A21, and Aβ42 M35 are shown. Upper panels show representative regions of the grids. Lower panels are high magnification images of the assemblies indicated by arrows in the upper panels. The colors in the lower panels correspond to those in the upper panels. Scale bars are 100 nm in the upper panels and 50 nm in the lower panels. Arrows in the lower panels indicate the periodicity of helical segments of fibrils. Blue arrows in D-L17 Aβ40 and D-N27 Aβ40 indicate short fibrils. The asterisk in D-M35 Aβ42 indicates a trifilar structure.
