Figure 4 | Scientific Reports

Figure 4

From: Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways

Figure 4

ALC potentiates KET-induced apoptosis. (a) ALC (60 mM) potentiated KET (100 μM)-induced apoptotic changes investigated by AO-EB staining. The yellow arrows represent normal nuclei in the control group. The red arrows represent apoptotic changes after ALC and/or KET treatment. Scale bar = 20 μm. (b) ALC (60 mM) potentiated KET (100 μM)-induced sub-G1 phase increase investigated by flow cytometry analysis. *p < 0.05, **p < 0.01 compared with the control group. # p < 0.05, ## p < 0.01 compared with the group treated with ALC and KET. $$ p < 0.01 compared with the group treated with ALC.

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