Figure 1 | Scientific Reports

Figure 1

From: Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in mice

Figure 1

Mouse models of IA. (A) Schematic representation of the three mouse models of IA that were used in the present study: p47 phox−/− CGD mice (upper panel), hydrocortisone-treated C57BL/6 mice (middle panel), and neutropenic C57BL/6 mice (lower panel). Grey arrows indicate the times of administration of hydrocortisone or anti-mouse Gr-1 monoclonal antibody, and black arrows at day 0 indicate the time of infection with A. fumigatus conidia, and black arrows at days 1, 3 and 5 indicate the time of euthanization to harvest lungs, serum and BALF for assessment of GT and bmGT levels, and/or histological analyses, and/or transcriptional analyses and/or tissue fungal burden. SubQ, subcutaneous; IP, intraperitoneal. (B) Representative survival curves of p47 phox−/− CGD mice (upper panel), hydrocortisone-treated mice (middle panel), and neutropenic mice (lower panel) infected with A. fumigatus conidia.

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