Figure 7
The induction of GT and bmGT biosynthetic genes does not correlate with the host-specific accumulation of GT and bmGT in the mouse models of IA. Shown is the induction of gtmA, gliP, gliT, gliF, and gliM in the A. fumigatus-infected lung for each mouse model, depicted as fold-change in the amount of mRNA of target gene in vivo relative to the amount in in vitro cultures of A. fumigatus (reference standard). * P < 0.05; ** P < 0.01; *** P < 0.001. Data represent the mean ± SEM. Two independent experiments produced similar results with a total of 4–6 mice per time-point.
