Table 1 Detection of GT and bmGT in sera and BALF during the course of IA.

From: Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in mice

Model of IA and day post-infection

GT

bmGT

Serum

BALF

Serum

BALF

CGD

Day 1

0%

0%

0%

0%

Day 3

0%

0%

0%

0%

Day 5

0%

0%

0%

0%

Steroid-treated

Day 1

0%

0%

0%

0%

Day 3

0%

0%

0%

0%

Day 5

0%

0%

0%

0%

Neutropenic

Day 1

0%

0%

0%

0%

Day 3

71% 55 (14–95)

50% 15 (8–22)

0%

0%

Day 5

40% trace amounts at the limit of detection of the assay (~1 ng/mL)

40% 7 (2–11)

0%

0%

  1. Presented is the % mice with detectable GT or bmGT in serum or BALF samples at the indicated time-point after infection in each mouse model of IA.
  2. Values are in ng/mL of serum or BALF and represent the mean with the range shown in parentheses among positive samples.