Table 3 Description of the genes and polymorphisms analyzed.

From: Pharmacogenetics of methylphenidate in childhood attention-deficit/hyperactivity disorder: long-term effects

Gene

Description

Variant

Reference

SLC6A2

Norepinephrine transporter

rs28386840a

44

  

r5569c

18

ADRA2A

Adrenergic receptor alpha 2A

rs1800544a

18

  

rs553668e

18

SLC6A3

Dopamine transporter

rs2550948b

45

  

rs2652511b

45

  

rs11564750a

45

  

3’UTR VNTRe

18

  

Intron8 VNTRd

18

DRD2

Dopamine receptor D2

rs1800497f

46

DRD4

Dopamine receptor D4

rs3758653a

47

  

Exon3 VNTRc

46

  

Promoter duplicationb

46

SLC6A4

Serotonin transporter

Promoter VNTRb

18

  

Intron2 VNTRd

18

HTR2A

Serotonin-2A receptor

rs7322347d

48

HTR2C

Serotonin-2C receptor

rs6318c

49

GRM7

Glutamate receptor metabotropic 7

rs3792452d

50

SLC9A9

Glycine transporter

rs9810857f

51

COMT

Catechol-O-methyltransferase

rs4680c

18

  

rs4818c

52

SNAP25

Synaptosomal-associated protein 25kDA

rs3746544e

18

DDC

Dopa decarboxylase

rs6592961d

48

STS

Steroid sulfatase

rs12861247d

53

  

rs17268988d

53

FADS2

Fatty acid desaturase 2

rs498793d

54

ADGRL3

Adhesion G protein-coupled receptor L3

rs1397548c

27

  

rs2305339d

27

  

rs6551655d

27

  

rs1868790d

30

  

rs6813183d

30

  

rs6858066d

30

CDH13

Cadherin 13

rs6565113d

47

GFOD1

Glucose-fructose oxidoreductase domain containing 1

rs552655d

47

  1. Position in the gene: aUpstream variant, bPromoter variant, cExon variant, dIntron variant, e3′UTR variant, fDownstream variant.