Table 3 Comparison of the genotypes and serum lipid levels in the Han and Maonan populations.

From: The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits

Genotype

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoA1 (g/L)

ApoB (g/L)

ApoA1 /ApoB

rs2483058

Han

  GG

514

4.81 ± 0.93

1.41 (0.60)

2.09 ± 0.57

2.87 ± 0.73

1.29 ± 0.14

0.84 ± 0.17

1.60 ± 0.37

  GC

495

4.75 ± 1.22

1.43 (0.60)

2.03 ± 0.64

2.79 ± 0.88

1.28 ± 0.17

0.83 ± 0.22

1.63 ± 0.44

  CC

201

4.89 ± 1.07

1.42 (0.72)

1.99 ± 0.52

2.93 ± 0.81

1.20 ± 0.22

0.86 ± 0.20

1.47 ± 0.41

  F

 

1.234

0.162

3.449

2.311

19.174

1.999

10.746

  P

 

0.291

0.741

0.037

0.100

9.5E-005

0.136

1.1E-006

Maonan

  GG

421

5.23 ± 1.11

1.46 (0.77)

1.53 ± 0.39

2.81 ± 0.82

1.29 ± 0.16

0.87 ± 0.20

1.56 ± 0.45

  GC

593

5.22 ± 0.98

1.44 (0.73)

1.49 ± 0.38

2.84 ± 0.76

1.30 ± 0.17

0.88 ± 0.18

1.55 ± 0.38

  CC

220

5.25 ± 1.03

1.44 (0.67)

1.45 ± 0.40

2.80 ± 0.80

1.20 ± 0.19

0.89 ± 0.19

1.44 ± 0.42

  F

 

0.074

0.223

3.303

0.322

24.020

0.308

7.037

  P

 

0.929

0.451

0.024

0.725

1.8E-007

0.735

0.001

rs2580520

Han

  GG

89

4.66 ± 1.06

1.44 (0.61)

2.04 ± 0.64

2.90 ± 0.79

1.27 ± 0.15

0.85 ± 0.20

1.57 ± 0.37

  GC

419

4.69 ± 1.09

1.43 (0.63)

2.09 ± 0.54

2.80 ± 0.82

1.27 ± 0.23

0.82 ± 0.19

1.63 ± 0.46

  CC

702

4.83 ± 1.14

1.42 (0.76)

1.98 ± 0.51

2.76 ± 0.94

1.26 ± 0.19

0.83 ± 0.15

1.60 ± 0.49

  F

 

3.662

0.162

1.459

2.589

0.318

2.371

3.128

  P

 

0.026

0.651

0.233

0.076

0.727

0.094

0.044

Maonan

  GG

73

5.17 ± 1.03

1.41 (0.62)

1.51 ± 0.38

2.79 ± 0.73

1.28 ± 0.12

0.86 ± 0.18

1.55 ± 0.41

  GC

509

5.23 ± 0.99

1.43 (0.63)

1.47 ± 0.40

2.83 ± 0.83

1.27 ± 0.21

0.88 ± 0.20

1.52 ± 0.42

  CC

652

5.77 ± 1.23

1.42 (0.74)

1.52 ± 0.43

3.01 ± 0.96

1.31 ± 0.39

0.93 ± 0.19

1.48 ± 0.40

  F

 

11.127

0.182

1.781

4.491

2.308

4.958

1.635

  P

 

1.2E-006

0.622

0.169

0.011

0.100

0.007

0.195

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The value of triglyceride was presented as median (interquartile range) for not meet the normal distribution, the difference among the genotypes was determined by the Kruskal-Wallis test. The P-value calculated by ANCOVA, using general linear models, and adjusted for age, sex, BMI, smoking status, alcohol use, glucose and hypertension, P < 0.025 was considered statistically significant (corresponding to P < 0.05 after adjusting for 2 independent tests by the Bonferroni correction). n = sample size.
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