Table 4 Comparison of the genotypes and serum lipid levels between males and females in the Han and Maonan populations.

From: The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits

Ethnic/ Genotype

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoA1 (g/L)

ApoB (g/L)

ApoA1 /ApoB

rs2483058

Han/male

  GG

216

4.93 ± 0.78

1.31 (0.67)

2.01 ± 0.57

2.83 ± 0.64

1.28 ± 0.16

0.86 ± 0.15

1.53 ± 0.30

  GC

183

5.03 ± 1.26

1.30 (0.66)

2.04 ± 0.46

2.87 ± 0.90

1.26 ± 0.12

0.89 ± 0.24

1.57 ± 0.47

  CC

66

5.04 ± 0.90

1.33 (0.84)

1.96 ± 0.39

2.91 ± 0.70

1.24 ± 0.15

0.90 ± 0.17

1.36 ± 0.35

  F

 

2.877

0.603

0.475

1.183

7.479

0.508

7.421

  P

 

0.238

0.546

0.622

0.345

0.001

0.402

0.001

Han/Female

  GG

298

4.79 ± 1.02

1.36 (0.66)

2.16 ± 0.56

2.91 ± 0.79

1.30 ± 0.14

0.83 ± 0.17

1.65 ± 0.41

  GC

312

4.71 ± 1.16

1.35 (0.66)

2.14 ± 0.73

2.75 ± 0.83

1.26 ± 0.18

0.79 ± 0.19

1.67 ± 0.42

  CC

135

4.77 ± 1.12

1.35 (0.85)

2.01 ± 0.59

2.83 ± 0.84

1.19 ± 0.25

0.82 ± 0.21

1.53 ± 0.43

  F

 

2.213

0.557

3.559

2.717

17.657

2.803

5.419

  P

 

0.311

0.443

0.029

0.067

8.1E-005

0.061

0.005

Maonan/male

  GG

151

5.16 ± 0.97

1.32 (0.67)

1.49 ± 0.46

2.65 ± 0.88

1.29 ± 0.20

0.86 ± 0.23

1.60 ± 0.59

  GC

243

5.18 ± 0.92

1.33 (0.67)

1.42 ± 0.36

2.81 ± 0.76

1.28 ± 0.17

0.89 ± 0.18

1.50 ± 0.38

  CC

106

5.28 ± 1.02

1.34 (0.88)

1.40 ± 0.44

2.79 ± 0.74

1.21 ± 0.22

0.90 ± 0.17

1.39 ± 0.37

  F

 

0.529

0.224

2.662

1.929

5.683

1.273

7.174

  P

 

0.590

0.821

0.043

0.146

0.004

0.281

0.001

Maonan/Female

  GG

270

5.26 ± 1.18

1.31 (0.65)

1.58 ± 0.35

2.89 ± 0.76

1.29 ± 0.26

0.88 ± 0.19

1.54 ± 0.35

  GC

350

5.24 ± 1.02

1.34 (0.62)

1.52 ± 0.39

2.85 ± 0.77

1.30 ± 0.15

0.87 ± 0.18

1.58 ± 0.38

  CC

114

5.22 ± 1.03

1.33 (0.77)

1.49 ± 0.36

2.81 ± 0.90

1.20 ± 0.12

0.84 ± 0.22

1.48 ± 0.45

  F

 

0.054

0.904

1.897

0.456

22.151

0.305

2.877

  P

 

0.947

0.216

0.029

0.634

1.3E-006

0.737

0.057

rs2580520

Han/male

  GG

23

4.53 ± 0.95

1.34 (0.71)

1.92 ± 0.41

2.81 ± 0.64

1.27 ± 0.15

0.82 ± 0.23

1.73 ± 0.76

  GC

158

4.86 ± 1.01

1.32 (0.69)

2.06 ± 0.55

2.82 ± 0.90

1.28 ± 0.17

0.86 ± 0.18

1.54 ± 0.39

  CC

284

5.03 ± 0.99

1.33 (0.70)

1.99 ± 0.48

2.95 ± 0.70

1.29 ± 0.12

0.90 ± 0.20

1.49 ± 0.32

  F

 

3.465

0.523

1.202

1.283

0.237

2.980

5.504

  P

 

0.032

0.437

0.301

0.299

0.789

0.051

0.007

Han/Female

  GG

66

4.57 ± 1.17

1.32 (0.59)

1.99 ± 0.53

2.87 ± 0.96

1.26 ± 0.20

0.83 ± 0.12

1.54 ± 0.33

  GC

261

4.75 ± 1.13

1.30 (0.61)

2.10 ± 0.53

2.78 ± 0.84

1.27 ± 0.21

0.79 ± 0.19

1.68 ± 0.49

  CC

418

4.94 ± 1.06

1.31 (0.83)

2.08 ± 0.72

2.86 ± 0.81

1.25 ± 0.15

0.81 ± 0.20

1.61 ± 0.38

  F

 

3.581

0.649

0.757

0.765

0.898

1.004

3.325

  P

 

0.028

0.403

0.469

0.466

0.408

0.367

0.037

Maonan/male

  GG

26

5.08 ± 1.31

1.32 (0.67)

1.45 ± 0.42

2.79 ± 1.03

1.34 ± 0.21

0.91 ± 0.20

1.42 ± 0.34

  GC

211

5.26 ± 0.95

1.33 (0.67)

1.41 ± 0.43

2.79 ± 0.85

1.25 ± 0.24

0.90 ± 0.20

1.44 ± 0.42

  CC

263

5.92 ± 0.88

1.34 (0.88)

1.45 ± 0.40

2.69 ± 0.71

1.27 ± 0.15

0.89 ± 0.17

1.57 ± 0.49

  F

 

10.387

0.214

0.500

0.755

2.991

2.173

4.387

  P

 

1.1E-006

0.823

0.607

0.446

0.051

0.163

0.013

Maonan/Female

  GG

47

5.20 ± 1.19

1.38 (0.66)

1.56 ± 0.43

2.99 ± 0.92

1.30 ± 0.17

0.90 ± 0.19

1.56 ± 0.43

  GC

298

5.23 ± 1.02

1.39 (0.61)

1.50 ± 0.37

2.86 ± 0.82

1.29 ± 0.18

0.87 ± 0.20

1.51 ± 0.41

  CC

389

5.46 ± 1.11

1.35 (0.71)

1.55 ± 0.35

2.84 ± 0.73

1.27 ± 0.10

0.86 ± 0.19

1.54 ± 0.35

  F

 

4.409

0.889

1.220

0.923

0.954

1.060

0.663

  P

 

0.018

0.346

0.296

0.398

0.385

0.347

0.516

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The value of triglyceride was presented as median (interquartile range)for not meet the normal distribution, the difference among the genotypes was determined by the Kruskal-Wallis test.The P-value calculated by ANCOVA, using general linear models, and adjusted for age, sex, BMI, smoking status, alcohol use, glucose and hypertension, P < 0.025 was considered statistically significant (corresponding to P < 0.05 after adjusting for 2 independent tests by the Bonferroni correction). n = sample size.
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