Table 7 Lipid profiles according to the SRGAP2 rs2483058C-rs2580520G haplotype in the two ethnic groups.

From: The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits

Group

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoA1 (g/L)

ApoB (g/L)

ApoA1 /ApoB

Han plus Maonan

2444

 

  Carrier

250

5.32 ± 1.06

1.50 (0.69)

1.71 ± 0.58

2.86 ± 0.79

1.22 ± 0.14

0.88 ± 0.19

1.47 ± 0.47

  Non-carrier

2194

5.12 ± 1.22

1.54 (0.75)

1.78 ± 0.50

2.83 ± 0.94

1.28 ± 0.17

0.86 ± 0.20

1.57 ± 0.40

  F

 

11.231

0.164

3.026

2.333

33.325

2.694

6.540

  P

 

0.001

0.689

0.074

0.187

8E-008

0.101

0.011

Han

1210

 

  Carrier

106

4.98 ± 1.08

1.42 (0.73)

1.96 ± 0.47

2.85 ± 0.81

1.20 ± 0.20

0.85 ± 0.19

1.50 ± 0.51

  Non-carrier

1104

4.80 ± 1.07

1.48 (0.79)

2.06 ± 0.61

2.81 ± 0.92

1.27 ± 0.16

0.83 ± 0.20

1.60 ± 0.40

  F

 

0.186

0.553

3.454

1.423

20.542

0.449

8.021

  P

 

0.666

0.541

0.045

0.233

1.4E-006

0.503

0.005

Maonan

1234

 

  Carrier

148

5.46 ± 1.27

1.39 (0.60)

2.47 ± 0.43

2.87 ± 0.96

1.23 ± 0.23

0.91 ± 0.21

1.44 ± 0.44

  Non-carrier

1086

5.20 ± 1.00

1.53 (0.60)

2.50 ± 0.39

2.84 ± 0.77

1.28 ± 0.15

0.88 ± 0.19

1.55 ± 0.41

  F

 

15.074

1.484

3.499

2.333

24.174

2.195

1.164

  P

 

1.8E-005

0.266

0.038

0.092

1.8E-007

0.139

0.281

  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B. The value of triglyceride was presented as median (interquartile range)for not meet the normal distribution, the difference among the genotypes was determined by the Wilcoxon-Mann-Whitney test. n = sample size.
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