Figure 2
From: A progesterone-brown fat axis is involved in regulating fetal growth
Surgical ablation of interscapular BAT alters maternal and fetal metabolic profiles. (A) Schema summarising the key stages of mouse pregnancy over time and the time-points selected for the study of pregnancy and metabolism in iBAT ablated (iBATx) or sham-operated mice, as indicated by the arrows. (B) Maternal weight without uterine horn (Sham, n = 5–10; iBATx, n = 6–9). (C) Maternal serum cholesterol levels (Sham, n = 6–9; iBATx, n = 7–10). (D) Maternal liver triglyceride levels (Sham, n = 7–10; iBATx, n = 9–12). Data are represented as mean ± SEM, *p<0.05 for Sham versus iBATx comparison at a single pregnancy time-point as determined by unpaired Student’s t-test. (E) Weight of fetuses at GD18 (Sham, n = 46 fetuses from 7 mothers; iBATx, n = 51 fetuses from 9 mothers). (F) Weight of placentas at GD18 (Sham, n = 24 placentas from 4 mothers; iBATx, n = 25 placentas from 5 mothers). (G) Average number of fetuses per pregnancy at GD18 (Sham n = 7; iBATx n = 9). *p<0.05 as determined by unpaired Student’s t-test.
