Figure 3
From: Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Non-swapped domain arrangement as a result of single residue substitution. (a-b), Extracellular views of TRPV6* (a) and TRPV6cryst (b) with four subunits (A–D) each shown in different color. Note, the peripheral S1–S4 domains are adjacent to the S5–S6 pore domains of the same subunit in TRPV6cryst, while the adjacent domains are from neighboring subunits in TRPV6*. (c,d) Side views of one S1–S4 domain and two S5–S6 pore domains illustrating S4–S5 and S6-TRP helix connectivity unique to swapped (c) and non-swapped (d) architectures. (e,f) Close-up views of the regions surrounding L495 in TRPV6* (e) and Q495 in TRPV6cryst (f).
