Figure 4
From: Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Dramatic change in TRPV6 transmembrane domain connectivity as a result of single-residue substitution in S5. (a–d) Transmembrane portions of TRPV6* (leucine at position 495, left) and TRPV6cryst (glutamine at position 495, right) viewed parallel to the membrane. S4–S5 (upper row) and S6-TRP helix (bottom row) connectivity is illustrated by 2Fo-Fc (blue mesh, 1σ) and omit Fo-Fc (yellow mesh, 2.5σ) maps.
