Figure 5
From: Profiling of the metabolic transcriptome via single molecule molecular inversion probes
smMIP-based targeted RNA next generation sequencing can be used for adequate variant calling. Shown are the loci containing the IDH1-R132H mutation in E478 xenografts (a) and in a clinical grade III astrocytoma (c), this mutation was confirmed by genetic analysis), whereas the IDH1-R314C mutation in E98 cells could also be identified (b).
