Figure 5
From: Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering
Assessment of ectopic bone formation upon intramuscular implantation of hBMSC-seeded, gene-activated constructs at 3.5 months after implantation. (A) µCT imaging of BMP group, showing mineralization sites consistent with ectopic bone formation (indicated with yellow arrows and white rectangular frames). (B) Quantitation of calcium deposition in constructs showed significant mineralization only in the BMP group. (C) Mechanical testing indicated significantly elevated compressive Young’s modulus in the implanted constructs of the BMP group, suggesting robust bone matrix deposition. **p < 0.01.
