Figure 3 | Scientific Reports

Figure 3

From: CG200745, an HDAC inhibitor, induces anti-tumour effects in cholangiocarcinoma cell lines via miRNAs targeting the Hippo pathway

Figure 3

Anti-proliferative effects of gemcitabine plus cisplatin in combination with CG200745. (a) SNU-1196 cells were treated with indicated concentrations of gemcitabine plus cisplatin along with CG200745 and cell viability was assessed. G, gemcitabine; P, cisplatin; GP, gemcitabine plus cisplatin; CG, CG200745. (b) Cells treated with serial dose of gemcitabine plus cisplatin and CG200745 for 3 days showed downregulation of c-MET and upregulation of cleaved Caspase-3. GP50, gemcitabine IC50 plus cisplatin IC50; GP1, 1/64 dilution of GP50; GP2, 1/32 dilution of GP50; GP3, 1/16 dilution of GP50; GP4, 1/8 dilution of GP50.

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