Figure 6 | Scientific Reports

Figure 6

From: CG200745, an HDAC inhibitor, induces anti-tumour effects in cholangiocarcinoma cell lines via miRNAs targeting the Hippo pathway

Figure 6

Target gene identification by microarray analysis. (a) Gene expression profiles were analysed with Affymetrix Human Genechip 2.0, and 215 differentially expressed genes (cut-off: fold change ≥ 4, P < 1.0E−10) were further examined by IPA. The graph shows the top cellular functions at 24 h post-CG200745 (IC50) treatment. (b) Genes differentially expressed in response to CG200745 (IC50) treatment in SNU-1196 and SNU-1196/GR are shown in the heat map. Up- and downregulated genes are shown in red and green, respectively. (c) Top-ranked Hippo signalling-associated genes were downregulated (green). (d) Associations among highly ranked pathway-associated genes and corresponding protein levels were analysed following treatment with CG200745 (IC50) for 0, 24, and 48 h.

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