Table 1 Basic characteristics of the patients with PBC.

From: Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population

 

All patients

Female

Male

Female vs. Male

Total number

n = 1200a

n = 1060

n = 139

female: male = 7.63:1

Age of onset (mean years ± SD)

57 ± 12

57 ± 12

60 ± 11

ns

Liver biopsy

    Scheuer 0

9/808 (1.1%)

8/714 (1.1%)

1/94 (1.1%)

ns

    Scheuer 1

424/808 (52.5%)

376/714 (52.7%)

48/94 (51.1%)

ns

    Scheuer 2

223/808 (27.6%)

197/714 (27.6%)

26/94 (27.7%)

ns

    Scheuer 3

80/808 (9.9%)

68/714 (9.5%)

12/94 (12.8%)

ns

    Scheuer 4

72/808 (8.9%)

65/714 (9.1%)

7/94 (7.4%)

ns

Outcome

    hepatocellular carcinoma

22/1043 (2.1%)

17/922 (1.8%)

5/121 (4.1%)

ns

    liver transplantation

112/1199 (9.4%)

101/1060 (9.5%)

12/139 (8.6%)

ns

    fatal hepatic failure

8/1199 (0.7%)

5/1060 (0.5%)

3/139 (2.2%)

ns

Clinical stage at latest evaluation

    I

813/1136 (71.6%)

725/1006 (72.1%)

88/130 (67.7%)

ns

    II

188/1136 (16.5%)

163/1006 (16.2%)

25/130 (19.2%)

ns

    III

135/1136 (11.9%)

118/1006 (11.7%)

17/130 (13.1%)

ns

Concomitant diseases

    Sjögren’s syndrome

177/1043 (17.0%)

169/922 (18.3%)

8/121 (6.6%)

OR = 3.17, p = 0.0013

    systemic sclerosisb

49/1043 (4.7%)

47/922 (5.1%)

2/121 (1.7%)

ns

    Hashimoto’s thyroiditis

102/1043 (9.8%)

96/922 (10.4%)

6/121 (5.0%)

ns (OR = 2.23, p = 0.058)

    autoimmune hepatitis

82/1043 (7.9%)

76/922 (8.2%)

6/121 (5.0%)

ns

    Raynaud’s phenomenon

32/1043 (3.1%)

31/922 (3.4%)

1/121 (0.8%)

ns

    rheumatoid arthritis

44/1043 (4.2%)

43/922 (4.7%)

1/121 (0.8%)

OR = 5.87, p = 0.0485

Autoantibodies

    AMA

956/1085 (88.1%)

839/960 (87.4%)

117/125 (93.6%)

OR = 0.47, p = 0.0439

    ANA

752/1042 (72.2%)

693/926 (74.8%)

59/116 (50.9%)

OR = 2.87, p = 5.65 × 10−8

    gp210

331/1134 (29.2%)

290/1003 (28.9%)

41/131 (31.3%)

ns

    CENP-B

324/1166 (27.8%)

302/1031 (29.3%)

22/135 (16.3%)

OR = 2.13, p = 0.00153

    SS-A

178/1166 (15.3%)

166/1031 (16.1%)

12/135 (8.9%)

OR = 1.97, p = 0.0285

  1. The prevalence of complications and autoantibodies was compared between female and male patients with PBC; significantly increased number and frequency were highlighted in bold. ns: not significant.
  2. aThere are three patients whose information about sex, age and clinical symptoms was not available.
  3. bIncluding limited cutaneous systemic sclerosis (also known as CREST).
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