Table 2 Carrier frequencies for selected HLA alleles in PBC patients and controls.

HLA-A

n = 1200

n = 1196

    A*33:03 ^†

88

(7.3%)

199

(16.6%)

0.40 (0.30–0.52)

2.35 × 10⁻¹²

    A*02:01/07/18

395

(32.9%)

293

(24.5%)

1.51 (1.26–1.81)

5.29 × 10⁻⁶

HLA-B

n = 1200

n = 1196

    B*44:03 ^a

66

(5.5%)

187

(15.6%)

0.31 (0.23–0.42)

7.01 × 10⁻¹⁶

    B*07:02

90

(7.5%)

146

(12.2%)

0.58 (0.44–0.77)

1.11 × 10⁻⁴

HLA-DRB1

n = 1200

n = 1194

    DRB1*13:02 ^a

47

(3.9%)

175

(14.7%)

0.24 (0.17–0.33)

1.35 × 10⁻¹⁹

    DRB1*08:03 ^a

283

(23.6%)

179

(15.0%)

1.75 (1.42–2.16)

1.01 × 10⁻⁷

    DRB1*14:03

7

(0.6%)

32

(2.7%)

0.21 (0.09–0.49)

5.10 × 10⁻⁵

    DRB1*04:05

390

(32.5%)

292

(24.5%)

1.49 (1.24–1.78)

1.31 × 10⁻⁵

HLA-DQA1

n = 1198

n = 783

    DQA1*01:02 ^a

173

(14.4%)

208

(26.6%)

0.47 (0.37–0.59)

2.20 × 10⁻¹¹

HLA-DQB1

n = 1199

n = 1195

    DQB1*06:04 ^a

37

(3.1%)

171

(14.3%)

0.19 (0.13–0.28)

1.91 × 10⁻²²

    DQB1*03:01 ^a

144

(12.0%)

256

(21.4%)

0.50 (0.40–0.63)

6.76 × 10⁻¹⁰

    DQB1*06:01 ^a

520

(43.4%)

403

(33.7%)

1.51 (1.27–1.78)

1.25 × 10⁻⁶

    DQB1*04:01

378

(31.5%)

280

(23.4%)

1.50 (1.25–1.80)

9.20 × 10⁻⁶

    DQB1*04:02

137

(11.4%)

87

(7.3%)

1.64 (1.24–2.18)

4.99 × 10⁻⁴

HLA-DPA1

n = 1200

n = 783

    DPA1*01:03 ^a

585

(48.8%)

495

(63.2%)

0.55 (0.46–0.67)

2.58 × 10⁻¹⁰

HLA-DPB1

n = 1200

n = 1196

    DPB1*04:01 ^a

35

(2.9%)

131

(11.0%)

0.24 (0.17–0.36)

9.63 × 10⁻¹⁵

    DPB1*02:01

378

(31.5%)

485

(40.6%)

0.67 (0.57–0.80)

3.95 × 10⁻⁶

    DPB1*05:01

815

(67.9%)

729

(61.0%)

1.36 (1.15–1.60)

3.72 × 10⁻⁴