Figure 3 | Scientific Reports

Figure 3

From: Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases

Figure 3

Visualization of membrane nanotubes between MDA-231 cancer cells in a mouse  model of brain metastasis. (a) 3D reconstruction of a lattice-light sheet image taken ~10 μm below the cut surface of a live 100 µm thick brain slice at day 24 post-injection. Several nanotubes are visible, connecting between MDA-231GFP cells. Each grid = 2 µm. (b) Single, diagonal image plane from the 3 D reconstruction in (a) showing multiple nanotubes connecting MDA-231 cells. See also Movie 3 for unprocessed image sweep. (c) Histogram plots the distributions of lengths of nanotubes that interconnect MDA-231 cells (c), n = 27 nanotubes measured from 4 brain slices from 4 mice).

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