Figure 3
Reactivation-induced strengthening of extinction relies on L-type voltage-gated calcium channels. (A) Schematic representation of the experimental procedures. Fear conditioned rats were submitted to 30-min extinction session. A test was conducted in the next day and a retest 28 days later. In the interval between tests, animals were reactivated by 3-min on days 7, 14 and 21 after test 1. Nimodipine (N = 15) or its vehicle (N = 12) were s.c. infused 30 min prior each reactivation (B) Freezing levels during extinction session. (C) Freezing levels during test. (D) Freezing levels during reactivations. (E) Freezing levels during retest. (*) Significant differences between groups (P < 0.05, Two-Way or Repeated-Measures ANOVA followed by Tukey’s post-hoc test).
