Figure 5
Post-reactivation infusion of NaB, a memory-enhancing drug, also strengthens extinction trace by preventing rapid reacquisition of fear. (A) Schematic representation of the experimental procedures. Fear conditioned rats were submitted to 30-min extinction session. A reactivation was conducted 24 h later followed by the immediate administration of sodium butyrate (NaB; N = 12) or its vehicle (N = 12). In the next 3 days, animals underwent test sessions ending with the delivery of a weak footshock plus additional 30 s of contextual exploration (rapid reacquisition protocol). One day later, a standard test was conducted. (B) Freezing levels during extinction session. (C) Freezing levels during reactivation. (D) Freezing levels during tests. (*) Significant differences between groups (P < 0.05, Independent-samples t test or Repeated-Measures ANOVA followed by Tukey’s post-hoc test).
