Figure 3
Implementation of the motion correction algorithm in clinical RSOM55. (a) Skin surface detected in the raw data before and after motion correction. Periodic disruptions due to breathing are visible in the uncorrected data. (b) Vertical MAPs before and after motion correction. Psoriatic skin shows typical thickening of epidermis, broadening of capillary loops, and increased blood volume fraction. The labels “(c)” and “(d)” mark the location of the epidermal-dermal junction and the dermal layer shown as lateral MAPs in panels c and d respectively (c) Lateral MAP of the epidermal-dermal junction. Broadening of capillary loops in psoriatic skin is visible after motion correction. Capillaries in healthy skin are too small to be captured by RSOM55. (d) Lateral MAP of an extensive vascular network in the dermal layer, showing well-resolved microvessels (green) only after motion correction. Scale bar, 250 µm. Abbreviations: d: depth; fs: fast-scanning; ss, slow-scanning.
