Table 3 Summary of the pharmacokinetic (PK) parameters of trans-resveratrol (t-Rev) following intravenous or oral administration of t-Rev-loaded PP123 self-assembling lecithin-based mixed polymeric micelles (saLMPMs) and a t-Rev/HP-β-CD complex solution (n = 3).

Dose (mg/kg)

20

20

40

40

k_el (1/hr)

0.05 ± 0.02

0.03 ± 0.01

0.16 ± 0.07

0.04 ± 0.01

t_1/2 (h)

17.17 ± 8.40

24.76 ± 6.63

4.76 ± 1.98

17.87 ± 6.15

T_max (h)

0.54 ± 0.65

1.00 ± 0.71

C_max (μg/ml)

1.28 ± 0.19

2.82 ± 0.14

AUC_0-72 (h.μg/ml)

4.47 ± 0.29

9.70 ± 4.04

1.10 ± 0.47

12.61 ± 4.06

V (L/kg)

112.2 ± 56.5

84.14 ± 30.64

297.9 ± 229.5

81.5 ± 1.94

CL (L/h/kg)

4.48 ± 0.29

2.30 ± 0.86

39.88 ± 1.63

3.35 ± 1.08

MRT(hr)

13.20 ± 7.38

24.49 ± 2.49

2.12 ± 1.63

17.84 ± 8.90

F_ab (%)

100

217

12

141

F_rel (%)

100

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