Figure 1 | Scientific Reports

Figure 1

From: Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

Figure 1

Effects of vildagliptin and metformin on SHR characteristics. Eight week old spontaneously hypertensive rats (SHR) rats were injected at t = 0 with streptozotocin (STZ, 60 mg/kg) or saline (non-STZ) to induce type-1 diabetes mellitus or not before they were treated for 12 weeks either with vildagliptin (10 mg/kg/day; open triangles) or metformin (300 mg/kg/day; open squares), or remained untreated (closed circles). Shown are the over time effects on (A) blood glucose, (B) body weight, (C) food intake, (D) urine production and (E) water intake. Data are mean ± SEM (n = 6–8 for each group). *Indicates p < 0.05 vs. untreated (STZ-)SHR at a specific time point; #indicates p < 0.05 vs. untreated (STZ-)SHR for the whole curve.

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