Table 3 Summary of directional changes in endothelial mediators in acetylcholine-induced relaxation in SHR aorta: effect of treatments.
Effect of treatment in | Total relaxation | PGs (sensitive to INDO) | NO (sensitive to LNMMA) | EDHF (INDO + LNMMA resistant) |
|---|---|---|---|---|
SHR | ||||
vildagliptin | ↑↑ | ↑↑ | ≈ | ≈↑ |
metformin | ↑↑ | ≈↓ | ↑↑ | ↑↑ |
STZ-SHR | ||||
vildagliptin | ≈ | ≈↓ | ≈↓ | ↑↑ |
metformin | ↑↑ | ≈ | ≈ | ↑↑ |
