Figure 2 | Scientific Reports

Figure 2

From: Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

Figure 2

Sepsis induces atrophy of locomotor muscles but no respiratory muscle. Gastrocnemius (n = 9–11/group) and diaphragm (n = 9–11/group) muscle weights (A). Representative images of a cross-section of gastrocnemius muscle immunostained with laminin and quantification of muscle fiber cross-sectional area (n = 8–9/group) (B). Numbers of macrophages per field (n = 5–8/group) (C). Forelimb and hindlimb muscle force (n = 9/group) (D). D-1: one day before CLP; D1: one day after CLP; D2: 2 days after CLP; D4: 4 days after CLP; D7: 7 days after CLP. Data are expressed as means ± SEM. a: significantly different from Sham mice; b: significantly different from D1; c: significantly different from D4. †: significantly different from gastrocnemius muscle at the same time point. **p < 0.01 and ***p < 0.001: significantly different from D1.

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