Figure 8 | Scientific Reports

Figure 8

From: Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

Figure 8

Graphical abstract of the study. Locomotor muscles are more prone to sepsis-induced muscle mass loss compared to the diaphragm respiratory muscle. Mechanistically, this could be explained by a larger increase in the expression of atrogenes (MuRF-1, MAFbx, Musa1) and by a strong increase in myostatin expression. Activation of anabolic pathways (Akt-mTOR and BMP/Smad1-5-8) in locomotor muscles is interpreted as a compensatory response triggered to limit the extent of sepsis-induced muscle atrophy. Physiologically, maintaining and/or increasing the mechanical load of diaphragm muscle during experimental sepsis could contribute to preserve diaphragm muscle from atrophy.

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