Table 4 The influence of different antiretroviral regimens and drugs on liver function parameters in 71 children without HBV or HCV coinfection.
From: Prevalence and predictors of liver disease in HIV-infected children and adolescents
parameter | Number of patients (%) | ALT | AST | bilirubin | GGTP | APRI | FIB-4 |
|---|---|---|---|---|---|---|---|
Drug/regimen | β (SE), p value | β (SE), p value | β (SE), p value | β (SE), p value | β (SE), p value | β (SE), p value | |
2 NRTI + NNRTI | 32 (45) | — | — | −5.85 (1.26), <0.0001 | 13.76 (3.34), 0.0001 | — | — |
2 NRTI + PI | 28 (39) | — | — | 6.62 (1.24), <0.0001 | −9.69 (3.60), 0.009 | — | — |
3TC | 55 (77) | — | 5.62 (2.52), 0.02 | — | — | — | — |
ZDV | 24 (34) | — | 5.31 (2.21), 0.01 | — | — | 0.05 (0.02), 0.02 | — |
TDF | 10 (14) | — | −8.35 (2.97), 0.006 | — | — | — | — |
NVP | 18 (25) | — | — | — | 15.14 (3.81), 0.0002 | — | −0.10 (0.03), 0.007 |
EFV | 14 (20) | — | −7.53 (2.59), 0.004 | −6.07 (1.65), 0.0005 | — | — | 0.11 (0.04), 0.01 |
LPV/r | 28 (39) | — | — | 5.91 (1.29), <0.0001 | −12.51 (3.46), 0.0006 | — | — |
DRV/r | 5 (7) | — | −8.47 (4.14), 0.04 | — | — | — | — |
