Figure 7
From: The parathyroid hormone regulates skin tumour susceptibility in mice
A schematic drawing of the mechanisms of a genetic polymorphism in Pth conferring resistance to two-stage skin carcinogenesis in mice. This figure shows a flow chart of how a genetic polymorphism in Pth changes the resistance to the chemically induced skin carcinogenesis between FVB/N and MSM/Ms. Secreted PTH is increased by elongating the protein half-life in MSM, which could lead to an increase in serum iPTH. Furthermore, serum intact-PTH increases the intracellular calcium in keratinocytes, which enhances the differentiation and suppresses proliferation of keratinocytes by the endocrine route. As a result, a polymorphism in Pth leads to resistance to chemically induced skin carcinogenesis in MSM.
