Figure 6 | Scientific Reports

Figure 6

From: The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice

Figure 6

Sul-121 treatment restores endothelium mediated relaxation. (A) Relaxations to acetylcholine were reduced in aortic rings of db/db vehicle indicating endothelial dysfunction. Sul-121 restored relaxation to lean vehicle values. (B) Dissection of the components involved in relaxation demonstrated a significant increase of the combined NO + PG component in db/db Sul-121 vs db/db vehicle. *p < 0.05 db/db Sul-121 vs db/db vehicle. (C) Sensitivity of the aortic rings to the NO donor SNP demonstrated decreased NO sensitivity in db/db vehicle. *p < 0.05 db/db vehicle vs lean vehicle, #p < 0.05 db/db Sul-121 vs db/db vehicle.

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