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Figure 1

From: Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer’s disease

Figure 1

Memory acquisition is impaired in Drosophila expressing Aβ42. Flies were trained at days 1 (a), 5 (b), 15 (c), or 30 (d) post-eclosion using olfactory classical conditioning and tested immediately after training. Memory performance index is shown for control flies (UAS-LacZ/+; ok107-Gal4/+) and flies expressing Aβ42 in MB neurons (UAS-Aβ42/+; UAS-LacZ/+; ok107-Gal4/+). Control flies show physiological memory decay through aging (Tukey’s comparison test: day 1 vs day 5, p = 0.0275; day 5 vs day 15, p = 0.9873; day 15 vs day 30, p < 0.0001; day 1 vs day 30, p < 0.0001; day 5 vs day 30, p < 0.0001). Flies expressing Aβ42 exhibit lower memory values (Tukey’s comparison test: day 1 vs day 5, p = 0.7981; day 5 vs day 15, p = 0.6533; day 15 vs day 30, p = 0.3108; day 1 vs day 30, p = 0.0065; day 5 vs day 30, p = 0.0419). Flies expressing Aβ42 show lower memory index than control flies at each time point (t-test comparison: day 1, p < 0.0001; day 5, p < 0.0001; day 15, p < 0.0001; day 30, p < 0.0001). Error bars indicate SEM; n = 10 per group; ***p < 0.001.

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