Table 7 Shock avoidance of flies co-expressing scFvs and Aβ42.

From: Anti-Aβ single-chain variable fragment antibodies restore memory acquisition in a Drosophila model of Alzheimer’s disease

Genotype

90 V Shock Avoidance

p-value

1-UAS-LacZ/+; ok107-Gal4/+

0.6744 ± 0.0513

—

2-UAS-Aβ42/+; UAS-LacZ/+; ok107-Gal4/+

0.7611 ± 0.0368

0.9106

6-UAS-Aβ42/UAS-svFv9; ok107-Gal4/+

0.6795 ± 0.0274

0.9999

7-UAS-Aβ42/+; UAS-svFv42.2/+; ok107-Gal4/+

0.8149 ± 0.0201

0.3698

8-UAS-Aβ42/UAS-svFv9; UAS-scFv42.2/+; ok107-Gal4/+

0.7287 ± 0.0438

0.9929

9-UAS-Aβ42/UAS-svFv9

0.6518 ± 0.0416

0.9999

10-UAS-Aβ42/+; UAS-svFv42.2/+

0.6723 ± 0.0415

0.9999

11-UAS-Aβ42/UAS-svFv9; UAS-scFv42.2/+

0.6473 ± 0.0507

0.9997

  1. Avoidance to an electric shock of 90 V for each corresponding genotype and their p-value for statistical significance versus the control (#1).
Back to article page