Figure 7 | Scientific Reports

Figure 7

From: Dianxianning improved amyloid β-induced pathological characteristics partially through DAF-2/DAF-16 insulin like pathway in transgenic C. elegans

Figure 7

DXN inhibiting Aβ toxicity was at least partially mediated by DAF-16. (A) DXN inhibiting worm paralysis induced by Aβ over-expression was partially reverted by daf-16 RNAi. (B) The effect of DXN was similar partially reverted by daf-16 deletion. (C) Pdaf-16::gfp reporter was induced in worm strain TJ356 after treatment with 15 mg/mL DXN, and heat shock treatment at 37 °C for 15 min as a positive control. The scale bar was 80 μm. (D) Quantification of DAF-16 nuclear localization. In A and B, data are the average of three replicates with about 120-180 worms in each group. In C and D, animals were about 90 individuals. ***Indicated that there was significant difference between treatment group and control group at P < 0.001. There is significant difference among these groups when symbols are different (P < 0.05).

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