Figure 4 | Scientific Reports

Figure 4

From: Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer

Figure 4

SR141716 inhibits canonical and activates non-canonical Wnt pathways in CRC cell lines. Western blot analysis for transducers of the canonical Wnt pathway (a) and for APC (b) in whole cell extracts from HCT116 and SW48 cultured for the indicated time in the presence (+) of SR141716 (SR) or vehicle alone (−). (c) Western blot analysis for CaMKII (total and phosphorylated), Wnt5, and ROR2 in whole cell extracts from HCT116 and SW48 cultured for 8 hours with SR141716 (+) or vehicle (−). GAPDH was used as protein loading control. Cropped blots from full-length gels are displayed in a, b and c.

Back to article page