Figure 7

SR141716 interacts with p300/KAT3B. (a) 3D docking models of SR141716 (colored by atom types: C green, O red, N blue, polar H light gray, Cl dark green) in the binding site of p300/KAT3B (secondary structure depicted in orange ribbons) and (c) associated 2D interaction panel; (b) alternative 3D docking models of SR141716 and (d) associated 2D interaction panel. Residues in the active site are represented in sticks (colored by atom types: C grey, N blue, O red, S yellow, H light gray). H-bonds ligand/protein interactions are represented in green dotted lines, while π-π interactions are depicted with cyan dotted lines and halogen bonds are reported with violet dotted lines. (e) Sensorgrams obtained from different injections (0.62, 1.25, 2.5, 4 and 5 μM) of SR141716 to immobilized hKAT3B/p300 (catalytic domain, aa 1284–1673).