Figure 2

Mllt10-KO embryos exhibit severe midline facial cleft and hypertelorism. (a–c) Normal craniofacial development of wild-type embryos during E11.0 to E12.5. (d–f) Abnormal craniofacial development of Mllt10-KO embryos, includes midline facial cleft (arrowheads). Scale bars; 500 μm. (g) The distance between the eyes and between the nostrils was measured. WT; wild-type, Het; Mllt10-Het, KO; Mllt10-KO. Data are mean ± s.e. of 5 embryos. Statistical differences were assessed with Student’s t-test, and p-values are shown. (h and i) Hematoxylin/Eosin staining of transverse sections at nasal level are shown. Splitting of nasal septum is indicated by arrow. Curvature of the nasal processes is indicated by dotted-line. ns; nasal septum, t; tongue. Scale bars; 500 μm.