Table 2 Baseline histopathological examination and fluorescence immunohistochemical staining of renal biopsies.

From: Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

 

IgA+, N = 73

IgA−, N = 425

P value

Histopathological characteristics (severity score)

Pathological stage

1.88 ± 0.73

1.65 ± 0.57

0.003

Mesangial cell proliferation

0.82 ± 0.82

0.36 ± 0.65

<0.001

Mesangial matrix expansion

0.96 ± 0.90

0.59 ± 0.86

0.001

Segmental sclerosis n, (%)

18 (4.7%)

55 (12.9%)

0.009

Crescent n, (%)

4 (5.5%)

17 (4.0%)

0.790

Inflammatory cell infiltration

0.86 ± 0.54

0.72 ± 0.57

0.043

Interstitial fibrosis

0.71 ± 0.61

0.60 ± 0.61

0.153

Tubular atrophy

0.78 ± 0.58

0.72 ± 0.57

0.404

Renal interstitial lesions stage

0.78 ± 0.58

0.68 ± 0.59

0.183

Arteriole hyperplasia n, (%)

24 (32.9%)

95 (22.4%)

0.051

Arteriole hyalinosis n, (%)

30 (41.1%)

108 (25.4%)

0.006

Arteriole lesions n, (%)

43 (58.9%)

159 (37.4%)

0.001

Fluorescence immunohistochemical staining (staining intensity score)

IgG

2.84 ± 0.41

2.79 ± 0.54

0.520

IgA

2.26 ± 0.44

0.04 ± 0.18

<0.001

IgM

0.62 ± 0.90

0.32 ± 0.65

0.008

C3

1.77 ± 0.91

1.59 ± 0.87

0.119

C4

0.24 ± 0.56

0.08 ± 0.33

0.059

C1q

0.37 ± 0.67

0.33 ± 0.61

0.622

Fibrinogen

0.40 ± 0.85

0.26 ± 0.60

0.199

  1. Data are presented as the mean ± standard deviation of severity score or staining intensity or the number of positive cases (% of total cases). Student’s t-test or the chi-square test was used to compare the values of the two groups.
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